PEG-b-P[Asp(DET)]

PEG-b-P[Asp(DET)] is a **polymer-drug conjugate** consisting of **poly(ethylene glycol) (PEG)** covalently linked in a block copolymer structure to **poly(aspartamide) (PAsp) chains functionalized with diethylenetriamine (DET) groups**. This copolymer is engineered to form micelles for drug delivery, especially nucleic acids like siRNA or plasmid DNA[3]. The PEG segment provides steric stabilization, biocompatibility, and extends circulation time in vivo, while the P[Asp(DET)] segment offers cationic charge for complexation with negatively charged nucleic acids. In acidic environments (e.g., tumor tissue or endosomes), the DET groups are protonated, which triggers membrane destabilization, improved endosomal escape, and efficient intracellular delivery. This pH-sensitive feature enhances the release profiles and gene silencing activity of loaded nucleic acids[3]. PEG-b-P[Asp(DET)] does not act directly on molecular targets but functions as a **non-viral gene delivery carrier**. It has been developed primarily in academic settings for nanomedicine research and preclinical studies.

Other names

poly(ethylene glycol)-block-poly(aspartamide) with diethylenetriamine functionalizationPEG-b-poly(aspartamide)[diethylenetriamine]PEG-b-PAsp(DET)